Fresh analysis suggests that individuals who come off new slimming jabs like Mounjaro or Wegovy may regain reduced body mass far faster than those who stop traditional diet and exercise plans.
Findings released in a prominent medical journal demonstrates that while overweight individuals can lose a large proportion of their body weight while on the medication, the weight comes back at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying such drugs should be aware of the potential of fast weight regain when the therapy is stopped," cautioned lead investigator Dr. Susan Jebb.
Such speed of regain means a reversion to pre-treatment weight in about one and a half years.
Comparing Treatments
The study, which examined dozens of trials involving thousands of participants, contrasted the effects of these new drugs with older methods.
The team emphasize that individuals who shed pounds through diet and exercise typically see a slower weight regain—approximately 0.1 kg a month—once they finish.
The Reason for the Fast Regain
Doctors suggest the mode of action of the drugs explains the amplified regain.
These medications mimic a natural hormone called glucagon-like peptide-1, which moderates appetite.
"Long-term administration of GLP-1 levels several times higher than the body's typical production may cause the system to generate a reduced amount of its own natural hormone, and may also reduce sensitivity to its actions," said Dr. Adam Collins, a nutrition expert.
"Discontinuation of this hormone supplement means appetite is no longer kept in check, making excessive eating a significant risk."
A Lifelong Disease?
Health authorities recommend the injections for individuals with weight-linked medical conditions, accompanied by prescribed lifestyle changes.
Many experts say that, considering the likelihood of relapse, the treatment should be considered long-term.
This opinion is reinforced by drug manufacturers, who state that the results "highlight the chronic nature of excess weight," similar to managing diseases like diabetes.
User Experiences
People who have come off the medication describe a intense resurgence of appetite.
"It felt as if a trigger flipping and you're instantly starving," described one woman.
This challenge is exacerbated if individuals have not adopted lasting lifestyle or habit changes during treatment.
Widespread Adoption
Recent estimates show that a significant number of adults in the UK have used weight-loss jabs in the last 12 months, with demand being substantial.
- Use is more common among women compared to males.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
In conclusion, researchers caution that while the jabs are potent agents for shedding pounds, they are not a magic solution and long-term success hinges on combined lifestyle support.
